Based on Russian research that has been ongoing since the 1970s, inflammation of the bone marrow of the subchondral bone causes increased pressure and congestion of channels that allow for delivery of oxygen, nutrients, and growth factors to the cartilage. This congestion both causes pain in the joint and promotes degeneration of the cartilage. Intraosseous restorative therapy alleviates this congestion and allows nutrients, oxygen, and growth factors to again reach the cartilage and promote healing.